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Noni Nitro™ Nitric Oxide Study
June 16, 2011
For
Sunland Source LLC 8070 La Jolla Shores Dr. Suite 450 La Jolla, CA 92037
Prepared by Baltimore Laboratories, Inc.
(203) 292-8797 95 Old Post Rd. PO Box 735 Southport, CT 06890

 

 

 

 

REFERENCES
J. Brice Weinberg; Thomas Lang et. al. Serum, Urinary, and Salivary Nitric Oxide in Rheumatoid Arthritis: Arthritis Research & Therapy. 2006;8(5)
Bryan, N. S. (2006). "Nitrite in nitric oxide biology: Cause or consequence? A systems-based review." Free Radic Biol Med 41(5): 691-701.
Bryan, N. S., B. O. Fernandez, et al. (2005). "Nitrite is a signaling molecule and regulator of gene expression in mammalian tissues." Nat Chem Biol 1(5): 290-7.
Bryan, N. S., T. Rassaf, et al. (2004). "Cellular Targets and Mechanisms of Nitros(yl)ation: An Insight into Their Nature and Kinetics in vivo." Proc. Natl. Acad
Sci. USA 101(12): 4308-4313.
Cosby, K., K. S. Partovi, et al. (2003). "Nitrite reduction to nitric oxide by deoxyhemoglobin vasodilates the human circulation." Nature Medicine 9: 1498-1505.
Gladwin, M. T., A. N. Schechter, et al. (2005). "The emerging biology of the nitrite anion." Nat Chem Biol 1(6): 308-14.
Grube, R., M. Kelm, et al. (1994). The Biology of Nitric Oxide. Enzymology, Biochemistry, and Immunology. S. Moncada, M. Feelisch, R. Busse and E. A. Higgs.
London, Portland Press. 4: 201-204.
Kelm, M. (1999). "Nitric oxide metabolism and breakdown." Biochim Biophys Acta 1411: 273-289.
Kelm, M., M. Feelisch, et al. (1992). The Biology of nitric oxide. Physiological and Clinical Aspects. S. Moncada, M. A. Marletta, J. B. Hibbs and E. A. Higgs.
London, Portland Press. 1: 319-322.
Kelm, M. and K. Yoshida (1996). Metabolic Fate of Nitric Oxide and Related N-oxides. Methods in Nitric Oxide Research. M. Feelisch and J. S. Stamler.
Chichester, John Wiley and Sons: 47-58.
Kleinbongard, P., A. Dejam, et al. (2006). "Plasma nitrite concentrations reflect the degree of endothelial dysfunction in humans." Free Radic Biol Med 40: 295302.
Kleinbongard, P., A. Dejam, et al. (2003). "Plasma nitrite reflects constitutive nitric oxide synthase activity in mammals." Free Radical Biology & Medicine 35(7):
790-796.
Larsen, F. J., B. Ekblom, et al. (2006). "Effects of dietary nitrate on blood pressure in healthy volunteers." N Engl J Med 355(26): 2792-3.
Lauer, T., M. Preik, et al. (2001). "Plasma nitrite rather than nitrate reflects regional endothelial nitric oxide synthase activity but lacks intrinsic vasodilator
action." Proc. Natl. Acad Sci. USA 98(22): 12814-12819.
Li, H., A. Samouilov, et al. (2004). "Characterization of the effects of oxygen on xanthine oxidase-mediated nitric oxide formation." J. Biol Chem 279: 1693916946.
Lundberg, J. O., S. Carlsson, et al. (1997). "Urinary nitrite: more than a marker of infection." Urology 50(2): 189-191.
Lundberg, J. O. and E. Weitzberg (2005). "NO generation from nitrite and its role in vascular control." Arterioscler Thromb Vasc Biol 25(5): 915-22.
Lundberg, J. O., E. Weitzberg, et al. (2004). "Nitrate, bacteria and human health." Nat Rev Microbiol 2(7): 593-602.
Moncada, S., R. M. J. Palmer, et al. (1991). "Nitric oxide: physiology, pathophysiology and pharmacology." Pharmacol Rev 43(2): 109-142.
Rhodes, P., A. M. Leone, et al. (1995). "The L-arginine:nitric oxide pathway is the major source of plasma nitrite in fasted humans." Biochem Biophys Res
Commun 209: 590-596.
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310-318.
Webb, A., R. Bond, et al. (2004). "Reduction of nitrite to nitric oxide during ischemia protects against myocardial ischemia-reperfusion damage." Proc Natl Acad
Sci USA 101(13683-13688).
Yoshida, K., K. Kasama, et al. (1983). "Biotransformation of nitric oxide, nitrite and nitrate." Int Arch Occup Environ Health 52: 103-115. Zweier, J. L., P. Wang, et al. (1995). "Enzyme-independent formation of nitric oxide in biological tissues." Nature Medicine 1(8): 804-809.

 

 

 

 

Noni Nitro™
Report for Sunland Source, LLC, In Vivo Nitric Oxide Enhancement by Noni Juice Concentrate.

 

Introduction:
From diabetes to hypertension, cancer to drug addiction, stroke to intestinal motility, memory and learning disorders to septic shock, sunburn to anorexia, male impotence to tuberculosis, there is probably no pathological condition where nitric oxide does not play an important role. Only recently (within the last 20 years) discovered as a product of enzymatic synthesis in mammals, there are more than 100,000 scientific papers dealing with this remarkable molecule with most of these published within the last five years.
It is well documented that nitric oxide, a gas, is not easily measured in the body but can be measured in bodily fluids, including saliva, by means of it's by-products, nitrate and nitrite. The major pathway for NO metabolism is the oxidation to nitrite (NO2-and nitrate (NO3- ) (Yoshida, Kasama et al. 1983). In plasma or other physiological fluids, such as saliva, NO is oxidized almost completely to nitrate and nitrite, where it remains stable for several hours (Kelm, Feelisch et al. 1992; Grube, Kelm et al. 1994). For this reason we have chosen salivary nitrite and nitrate measurements as a marker for in vivo NO levels. The quantification of NO metabolites in biological samples provides valuable information with regards to in vivo NO production, bioavailability, and metabolism.

 

Purpose:
This document reports to Sunland Source, LLC the results of the in vitro tests run on June 14, 2011. The object of the test was to measure the slope of Nitric Oxide "NO" change in saliva after ingesting a single dose of Noni Nitro. This was accomplished by measuring the NO by-products in saliva, nitrate and nitrite as established by (J. Brice Weinberg; Thomas Lang et. al.). Saliva samples were obtained as follows: a baseline sample prior to Noni Nitro ingestion, then serial samples for three hours each collected at the hour mark timed from Noni Nitro ingestion. The Noni Nitro dose was 0.8ml and each saliva sample was 2.5cc. Saliva samples were collected from 13 participants who self-rated their health as "good" to "healthy" .
The demographics of the study population are as follows: 7 Males, 12 Females, Minimum age 14, Maximum age 66, Average age 44. The minimum increase in NO production excluding anomalies was a 110% increase in NO. The highest increase in NO in an individual was more than 12.5 times the baseline.

 

Experimental Methods for Nitric Oxide Activity:
Measurements were made by means of electro-chemistry using ion specific electrodes and a laboratory grade electro-chemistry meter.
Salivary samples were collected in air-tight capped syringes and stored frozen until tested.

 

Study Limitations:
The investigators stipulate that the following limitations should be noted: •Sample size was small (N=19)
•Study participants are ethnically homogenous (all Caucasian), residing in the same geographical area

•The health rating was based on subjective sense of health as reported by the individual participant

•The timing of sample collections cannot be verified independently.

 

•The dose of Noni Nitro was drawn by each study participant and not pre-measured by the investigators (which is a possible advantage in that it may better reflect actual usage patterns in the general population). •The relationship of food to the timing of the Noni Nitro testing cannot be excluded as a confounding variable (i.e. - a nitrite containing hot dog eaten within hours of the testing time-frame may have had an effect on a participant's measured values).
•Concurrent medications and supplements cannot be ruled out as a confounding factor. Participants were asked to abstain from the study only if they were currently on anti-hypertensives or statins.

 

 

Results of Noni Nitro™ Tests:
Executive summary of results:
Average Increase in men 279.50%
Average Maximum increase in men 406.26%
Maximum Increase in men is 1252.60%
Average Increase in Women 132.42%
Average Maximum increase in Women 175.47%
Maximum Increase in Women is 220.51%

 

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